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Ultime notizie dal mondo della genetica


Two new extensions for CRISPR have been discovered

Two Broad Institute and Harvard University teams have developed new extensions for CRISPR. The two techniques allow you to rewrite single letters or DNA bases and RNA.

The CRISPR genetic editing technique cuts a section of the double helix of the DNA, replaced by a healthy version. It's an effective but somewhat violent approach to DNA. Extensions, on the other hand, allow you to act in a more targeted manner. Instead of cutting the double helix, they use enzymes to change the order of bases that make up DNA and RNA. This way you get a new base without acting on the surrounding ones.

Findings are particularly relevant for genetic diseases with point mutations. They are illnesses caused by changes in single nucleotides, where a single base is put in the wrong place.

The technique developed by David Liu acts on the layout of the adenine atoms and turns them into guanine. In this way, the pair of A-T bases becomes a C-G pair. The procedure proved to be effective in 50% of cases and did not lead to collateral changes.

The second technique, discovered by the Feng Zhang team, acts on the RNA. The researchers turned the adenine into iosin. The components that produce cellular proteins read iosin as guanine. The method allows you to make a temporary change only because it acts on the RNA and not on the DNA. This means that you can repeat the process several times, even by making improvements.

Source: focus.it

Red wine helps female fertility?

Researchers at the University of Washington have found that a glass of red wine a week helps female fertility. It is likely that the merit of antioxidants that abound in red wine.

Resveratrol is a key molecule in grapes of red grapes, cocoa and blueberries. It protects cells from biological stress and helps them live more and better. It is present in many foods, but red wine is not particularly rich.

Scientists interviewed 135 women between the ages of 18 and 44 on alcohol consumption. Each of them had to score how many spirits consumed every month and what kind. The researchers also examined the health status of women's ovaries and the number of remaining oocytes.

Beyond factors such as age and health, women who regularly consumed red wine had more oocytes. The benefits would be particularly marked in women who consumed 1-5 glasses of wine per month. We talk about regular, but moderate, non-daily consumption.

The results must be taken with caution. A link is obvious, but it is not known whether the merit is all about red wine or whether there are other factors in play. It will be necessary to consider a wider sample of women, also considering other elements. It is also important to remember that even a minimal exposure to alcohol can be detrimental to an embryo in the early stages of development.

Source: independent.co.uk

Male infertility: symptoms and causes

Male infertility is related to dysfunctions in different organs and tissues, which can not always be identified with certainty. Some of these are permanent, but others are manageable with lifestyle changes. The main causes are pre-testicular, testicular and post-testicular.

Pre-testicular causes are related to hormones that regulate testicular functions. The most common causes are the functioning of the pituitary gland, a fundamental endocrine gland for spermatogenesis. In some cases the gland does not produce enough FSH, the hormone that regulates the production of spermatozoa. By placing the testicles in optimum conditions, fertility should also be restored.

Testicular causes are the most common and concern the very structure of the testes. In the case of cryptorchidism, the testicles remain within the abdomen, reversible condition. Those suffering from varicocele, however, have veins of the testicle too dilated. This condition increases the body temperature, killing the sperm, and damaging the production itself. Finally, there are orchitis, that is, testicular inflammation that can damage the mechanisms of spermatogenesis.

Post-testicular causes touch the sperm passage outside of the gonads. In these cases infertility is caused by the failure of sperm output, which remain blocked. Obstruction can be caused by congenital malformations or with time. In some cases the cause is an inflammation or an alternate response of the immune system, which attacks spermatozoa.

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