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Aurora magazine

High resolution 3D digital model developed

In the last few decades, scientists have successfully mapped the human genome. Unfortunately there was nothing that corresponded to a high resolution model. This made it more difficult to study the interactions between chromosomes, which are intricate and essential to understanding so many diseases.

Researchers at the University of Missouri have perhaps solved this problem. The tool developed by the team creates a high resolution 3D model of the human genome. In this way it is easier to identify the factors that determine genetic diseases, tumors and disorders of various kinds. The researchers started with pre-existing one-dimensional sequencing. To add the missing dimensions, they have created an algorithm that displays interactions in 3D and high definition. Neighboring or linked genes are easier to identify, since their link is visually expressed.

Two genes apparently unrelated but close, for example, can explain the apparent anomalies of diseases such as diabetes or Alzheimer. The interaction between genes underlies the functioning of our body. This is why it is so important to be able to visualize it in the best possible way. Furthermore, this research underlines the power of transversal precision medicine. All this has in fact been made possible by the collaboration between several schools and among several faculties, the only way to develop an IT tool of this kind, potentially so important for medicine.