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Aurora magazine

Von Willebrand disease: causes and symptoms

Von Willebrand's disease is an inherited genetic disorder that causes problems related to blood clotting. In many ways it is similar to haemophilia: patients may experience post-operative bleeding and bleeding. The severity varies from case to case, based on the lack of the Willebrand factor, which is necessary for coagulation.

Depending on the factor level, you have the following types:

  • type 1, partial;
  • type 2 variants, with defects of different types in the factor;
  • type 3, total absence of the factor.

The cause is a mutation of the VWF gene, on chromosome 12, which codes for the factor. However, according to the scientists, other genes not yet identified could also be involved. In type 1 and type 2 disease, transmission is autosomal dominant: an altered copy is sufficient for the disease to manifest. In type 3 and in some type 2, the mode is autosomal recessive. Diagnosis is made by analyzing the patient's clinical and family history.

Subsequently, the dosage of Willebrand factor and others involved in coagulation is passed. In many cases it remains rather difficult to pose. Unfortunately, to date there are no solution therapies. Replacement Willebrand factor can help in severe cases, at least to stop bleeding. In milder cases, on the other hand, just dab the bleeding and apply pressure. Furthermore, those suffering from the disease should avoid the use of anti-aggregating and anticoagulant drugs such as aspirin.