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Aurora magazine

Lynch syndrome: causes and symptoms

Lynch syndrome is a genetic predisposition syndrome, also called Hereditary Non-Polyposis Colorectal Cancer (HNPCC). Those who suffer from it have many more chances to develop colorectal cancer throughout their lives. The syndrome also predisposes to other types of cancer, such as endometrial, ovarian, pancreas and others.

Although Lynch's syndrome is termed "Non-Polyposis", colonoscopy cancer usually develops from adenomatous polyps. These become malignant and cause cancer. Nonetheless, the polyps in question are much less numerous and diffused than in other pathologies such as the Family Adenomatosis Polypose.
Colon cancer cases are about 10-15% of all cancers. Their development involves both genetic and environmental factors such as fat-rich diet, poor fiber consumption, poor physical activity and obesity. This means that on the one hand Lynch syndrome increases the risk of tumor greatly, up to about 40-85%. On the other hand, who knows their situation is able to react with a healthy lifestyle and constant screening.

In the event of a diagnosis of Lynch's syndrome, doctors recommend that you follow the prevention program prepared by the International Study Group on Syndrome. This involves periodic examinations to detect possible traces of colorectal cancer and other organs. In the absence of symptoms, it is advised to carry out a colonoscopy annually. On this occasion, it is also possible to remove any adenomatous polyps. For the subject's family, however, it is good to check the presence of the genetic abnormality with the appropriate diagnostic screening.

The symptoms of Lynch's syndrome are the same as colon cancer: blood in the stools, constipation alternating with diarrhea, weight loss, exhaustion. Nevertheless, in the case of cancer caused by syndrome, doctors recommend more invasive therapies for preventive purposes.