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Aurora magazine

New research project against non-Hodgkin's lymphoma

Antonio Candidi was a boy from Lariano, who died in 2017 due to non-Hodgkin's lymphoma. Antonio's family and friends decided to celebrate the memory in the best way: helping to save other lives. They have in fact activated a sports tournament with a fundraiser, for the Italian Lymphoma Foundation (FIL). Thanks to their generosity and that of the participants, FIL will launch a new research project on the disease.

The project of the Italian Lymphoma Foundation will have the title "Comparison between Immunohistochemical and Gene expression of the metabolic pathways of BCL-2, CD38, PD1 and PD1-L through the NanoString platform in patients with Nodal Peripheral T-lymphoma". What is the goal behind such a long title?

Researchers will compare two techniques used to analyze genetic markers. They will focus in particular on mRNA molecules, responsible for encoding information during DNA transcription. Molecules carry information to sites where protein synthesis takes place. Their level of expression could therefore influence the response to drug therapies.

Understanding the link between mRNA expression levels and treatment efficacy is essential. It would allow to identify immediately the most effective drugs for a given patient. In this way it would be easier to maximize the effectiveness of the therapies thanks to customized solutions.

The researchers presented the project to the Lymphoma T Scientific Commission of the Italian Lymphoma Foundation, which has already approved it. Head of the study will be Professor Francesco Zaja, Head of the Hematology of the Integrated Healthcare University of Trieste (ASUITS), and Professor Stefano Pileri, Professor of Pathological Anatomy at the Alma Mater Studiorum and Director of the Unit of Diagnosis Emolinfopathology at the European Institute of Oncology in Milan.